Bristol Myers Squibb
is seeking a highly motivated student to join our Predictive Sciences group within the Oncogenesis Thematic Research Center for a 10-week summer internship program. A successful candidate will work with their mentor to interrogate the biological functions of oncogenic transcription factors Ikaros and Aiolos in Diffuse Large B Cell Lymphoma (DLBCL) by a retrospective analysis of multi-modal omics data.
DLBCL is an aggressive heterogeneous disease with poor prognosis associated with cell of origin or high-risk molecular features. Ikaros and Aiolos have been identified as key oncogenic drivers for DLBCL. Over the years, BMS has developed multiple cereblon (CRBN) modulating agents, from first-generation compounds like lenalidomide and pomalidomide to more recent golcadomide, to induce targeted degradation of Ikaros and Aiolos by hijacking the ubiquitin proteasome system. However, the specific regulatory roles and biological functions of Ikaros and Aiolos in DLBCL remain obscure.